Neutrophil Elastase (ELANE) (Native Protein)

Product information

Size

25 µg

Catalog number

30 600 202

Price

216 EUR

More information

Protein type

Native

Protein subtype

EC 3.4.21.37

Protein family

Member of a serine proteases that hydrolyze many proteins in addition to elastin

Protein description

ELANE modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

Research area interests

Diseases associated with ELANE include Neutropenia, Cyclic and Neutropenia, Severe Congenital 1, Autosomal Dominant. Among its related pathways are amb2 Integrin signaling and Cell adhesion_Cell-matrix glycoconjugates.

Package form

liquid

Tested applications

Degradation of extracellular matrix components such as elastin, cartilage proteoglycans, collagens, fibronectin; Screening and characterization of inhibitors; Drug target for emphysema, cystic fibrosis, adult respuratory stress syndrome and other diseases

Other names

Bone Marrow Serine Protease, Human Leukocyte Elastase, ELANE (Elastase, Neutrophil Expressed)

Peptide sequence

MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGMTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH

Available target modification

No

Expression system

Human Blood

Product Subtype

full length

Active form?

Yes

Tag

untagged

Contents

10 mM acetate buffer pH 5.5

Protein purity

>95%

Molecular weight

29 kDa

UniProt number

P08246

Gene number

1991

Abbreviation

ELANE

Full name

elastase, neutrophil expressed

Other desciption

Human neutrophil elastase (EC 3.4.21.37) from human neutrophils. Prepared from whole human blood shown to be non-reactive for HbsAG, antiHCV, anti-HBc, and negative for anti-HIV1 2 by FDA approved tests. The protein consists of a single polypeptide chain of 218 amino acids I30 ... Q247 with a relative molecular weight of about 29.5 kDa.

Purification

Mentioned in the data sheet

PubMed citations

See the data sheet

Warnings

For Research Use only.

Shipping conditions

dry ice

Storage condition

Store at -70°C

Technical datasheet

Contact us to receive the datasheet