Product information
Size
25 µg
Catalog number
30 600 202
Price
216 EUR
More information
Protein type
Native
Protein subtype
EC 3.4.21.37
Protein family
Member of a serine proteases that hydrolyze many proteins in addition to elastin
Protein description
ELANE modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Research area interests
Diseases associated with ELANE include Neutropenia, Cyclic and Neutropenia, Severe Congenital 1, Autosomal Dominant. Among its related pathways are amb2 Integrin signaling and Cell adhesion_Cell-matrix glycoconjugates.
Package form
liquid
Tested applications
Degradation of extracellular matrix components such as elastin, cartilage proteoglycans, collagens, fibronectin; Screening and characterization of inhibitors; Drug target for emphysema, cystic fibrosis, adult respuratory stress syndrome and other diseases
Other names
Bone Marrow Serine Protease, Human Leukocyte Elastase, ELANE (Elastase, Neutrophil Expressed)
Peptide sequence
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGMTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Available target modification
No
Expression system
Human Blood
Product Subtype
full length
Active form?
Yes
Tag
untagged
Contents
10 mM acetate buffer pH 5.5
Protein purity
>95%
Molecular weight
29 kDa
UniProt number
P08246
Gene number
1991
Abbreviation
ELANE
Full name
elastase, neutrophil expressed
Other desciption
Human neutrophil elastase (EC 3.4.21.37) from human neutrophils. Prepared from whole human blood shown to be non-reactive for HbsAG, antiHCV, anti-HBc, and negative for anti-HIV1 2 by FDA approved tests. The protein consists of a single polypeptide chain of 218 amino acids I30 ... Q247 with a relative molecular weight of about 29.5 kDa.
Purification
Mentioned in the data sheet
PubMed citations
See the data sheet
Warnings
For Research Use only.
Shipping conditions
dry ice
Storage condition
Store at -70°C
Technical datasheet
Contact us to receive the datasheet