Product information
Size
100 Tests
Catalog number
GEN632240
Price
757 EUR
More information
Also known as
TRAILR4
Other names
tumor necrosis factor receptor superfamily member 10D; Tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily member 10D; TRAIL receptor 4; decoy receptor 2; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; TNF-related apoptosis-inducing ligand receptor 4; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain
Category
Antibodies
Subcategory
Mnoclonal antibodies
Gene name
TNFRSF10D; TNFRSF10D; DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4; DCR2; TRAILR4; TRUNDD; DcR2; TRAIL receptor 4; TRAIL-R4
Gene name synonims
TNFRSF10D; TNFRSF10D; DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4; DCR2; TRAILR4; TRUNDD; DcR2; TRAIL receptor 4; TRAIL-R4
Other gene names
TNFRSF10D; TNFRSF10D; DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4; DCR2; TRAILR4; TRUNDD; DcR2; TRAIL receptor 4; TRAIL-R4
Clonality
Monoclonal
Immunoglobulin isotype
IgG1
Clone
11C53
Host organism
Mouse (Mus musculus)
Source organism
Human (Homo sapiens)
Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Specificity and cross-reactivity
Recognizes human TRAIL R4.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Purification method
Affinity Purified by immunoaffinity chromatography.
Form/Appearance
Supplied as a liquid in sodium chloride, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
Concentration
N/A
Storage and shipping
May be stored at Store the antibody at +4 degrees Celsius. before opening. DO NOT FREEZE! Stable at Store the antibody at +4 degrees Celsius. as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months. Prior to use, briefly centrifuge the original vial after thawing and before lid. If further dilution(s) are needed, they can be done with the appropriate assay buffer. Freezing Allophycocyanin conjugates will result in a substantial loss of enzymatic activity.
Tested applications:
Flow Cytometry (FC/FACS)
Tissue
tumor
Description
This 1 is suited for programmed cell-death studies.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Gene
Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.