SQSTM1 Antibody, HRP Conjugated

Product information

Size

0.1ml

Catalog number

bs-2951R-HRP

Price

350 EUR

More information

Long name

SQSTM1 Polyclonal Antibody, HRP Conjugated

Category

Conjugated Primary Antibodies

Conjugation

HRP

Host Organism

Rabbit (Oryctolagus cuniculus)

Target Antigen

SQSTM1

Specificity

This is a highly specific antibody against SQSTM1.

Modification

Unmodified

Modification site

None

Clonality

Polyclonal

Clone

Polyclonal antibody

Concentration

1ug per 1ul

Immunogen_range

80-130/440

Subcellular location

Cytoplasm, Nucleus

Source

KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62

Gene ID number

8878

Swiss Prot

Q13501

Tested applications

WB, IHC-P

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500)

Crossreactivity

Human, Mouse, Rat

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Antigen background

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Purification method

This antibody was purified via Protein A.

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Excitation Emission

N/A

Synonyms

p60; p62; A170; OSIL; PDB3; ZIP3; p62B; Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; SQSTM1; ORCA

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.

Additional conjugation

HRP Conjugated

French translation

anticorps