Rabbit Anti Human ATR Antibody-Non-conjugated

Product information

Size

100ug

Catalog number

CSB-PA622666LA01HU_100ug

Price

302 EUR

More information

Long name

Rabbit Antibody against Human ATR, Non-conjugated

Synonym name

ATR Human Antibody

Species reactivity

Human

Tested applications & recommended dilutions

ELISA,IHC;Recommended dilution:IHC:1:20-1:200

Conjugation

Non-conjugated

Antibody isotype

IgG

UniProt ID

Q13535

Format

Liquid, diluted in buffer

Buffer composition

Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Purity

>95%

Purification method

Protein G purified

Antibody category

Polyclonal Antibodies

Immunogen type

Recombinant human Serine/threonine-protein kinase ATR protein (2405-2644AA)

Immunogen species

Human

Alias

Serine/threonine-protein kinase ATR,Ataxia telangiectasia and Rad3-related protein,FRAP-related protein 1,ATR,FRP1

Background

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Clonality

Polyclonal antibody

Shipping and storage

ATR Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.

Short name of the antigen

Serine/threonine-protein kinase ATR

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.

Properties

If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

About

Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

Latin name

Oryctolagus cuniculus

French translation

anticorps