30 600 202
Member of a serine proteases that hydrolyze many proteins in addition to elastin
ELANE modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Research area interests
Diseases associated with ELANE include Neutropenia, Cyclic and Neutropenia, Severe Congenital 1, Autosomal Dominant. Among its related pathways are amb2 Integrin signaling and Cell adhesion_Cell-matrix glycoconjugates.
Degradation of extracellular matrix components such as elastin, cartilage proteoglycans, collagens, fibronectin; Screening and characterization of inhibitors; Drug target for emphysema, cystic fibrosis, adult respuratory stress syndrome and other diseases
Bone Marrow Serine Protease, Human Leukocyte Elastase, ELANE (Elastase, Neutrophil Expressed)
Available target modification
10 mM acetate buffer pH 5.5
elastase, neutrophil expressed
Human neutrophil elastase (EC 22.214.171.124) from human neutrophils. Prepared from whole human blood shown to be non-reactive for HbsAG, antiHCV, anti-HBc, and negative for anti-HIV1 2 by FDA approved tests. The protein consists of a single polypeptide chain of 218 amino acids I30 ... Q247 with a relative molecular weight of about 29.5 kDa.
Mentioned in the data sheet
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For Research Use only.
Store at -70°C
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